Hamlet (and yes, I have stressed this before) is the most oft-parodied play that I have found among others on television, movies, comics, etc. Here is more Hamlet hilarity with these videos.
This video, "Hamlet: Prince of YouTube," features a guy using the "To be or not to be" speech as a base to make fun of the woes of YouTube.
This video below is taken from the animated series Animaniacs. This cartoon parodies the scene where the skull of Yorick is dug up, with Dot translating what is being said into sarcastic, modern English.